Organisation
|
|
|
|
|
Aktivitäten
|
|
|
|
|
|
|
|
|
|
|
Kontakt |
|
|
|
|
|
|
Angebote für Studenten |
|
|
|
|
Bereiche im Nanotechnikum |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Martin-Luther-Universität
Interdisziplinäres Zentrum für Materialwissenschaften
Nanotechnikum Weinberg
Heinrich-Damerow-Str. 4, D-06120 Halle, Germany
|
|
H. Nitzsche, A. Lochmann, H. Metz, A. Hauser, F. Syrowatka, E. Hempel, T. Müller, T. Thurn-Albrecht, K. Mäder Fabrication and characterization of a biomimetic composite scaffold for bone defect repair J. Biomed. Mater. Res. 94A (1) (2010), 298-307
For successful bone tissue engineering, scaf- folds with tailored properties are a basic requirement. The combination of different available materials not only appears to be desirable but also very challenging. In this study, a composite material consisting of hydroxyapatite and collagen was produced by a biomimetic precipitation method and characterized by X-ray diffraction (XRD) and thermogravimetry (TGA). Subsequently, a suspension-quick-freezing and lyophilization method was used to incorporate the hydroxyapatite into a polymeric matrix consisting of collagen and chitosan. Before physicochemi- cal characterization, the highly porous scaffolds were con- solidated by a dehydrothermal treatment (DHT). The main attention was focused on the particle size of hydroxyapatite, which should be in the nanometer range. This is rele- vant to achieve a homogeneous resorption of the material by osteoclasts. Small-angle X-ray scattering (SAXS), atomic force microscopy (AFM), and environmental scanning electron microscopy (ESEM) were used to evaluate the out- come. The results suggest a successful polymeric embed- ding of nanoscaled hydroxyapatite particles into the matrix of the spongy construct. Keywords: biomaterials
DOI 10.1002/jbm.a.32703
© Wiley 2010
|
|
|
|